Yes, it is true that dropping NAD+ levels mark senescence in a variety of research on worms, rodents, and human cellular models
The trial delivered weight loss of less than 10%, far less than the amount Lilly reported
Our bodies make it naturally but several factors can affect its production
The presence of glutathione peroxidase 8 (GPx8) in rat male genital organs
Nevertheless, the convergence of (i) higher baseline CRP among improvers, (ii) the strong correlation with CRP/NLR and MELD, and (iii) the recognised role of glutathione in modulating redox-sensitive inflammatory pathways, does support a biologically coherent hypothesis: glutathione may be most useful in patients with an inflammatory phenotype, where oxidative stress and systemic inflammation are dominant, modifiable drivers of acute decompensation ( FIGURE 8 The apparent counter-intuitive finding that patients with higher baseline MELD, bilirubin, INR and CRP were more likely to improve also fits this picture